Course on Early Phase Dose Finding Methods
Matthieu Clertant * Alexia Iasonos * John O'Quigley * Graham Wheeler
The course will take place over 2 days at the London Mathematical Society, 57-58 Russell Square, WC1B 4HS (on the corner with Southampton Row). Euston Station, St Pancras Station and Kings Cross Station are all within walking distance. Russell Square and Holborn tube stations nearby.
First day. Wednesday, November 15th 2017
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9.00 - 9.30 Welcome, coffee, juice, croissants
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9.30 - 10.15 Introduction, background, important ideas, Alexia Iasonos
10.15 - 11.00 Model based designs and their interrelationships John O'Quigley
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11.00 - 11.15 Coffee break
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11.15 - 12.00 Performance, accuracy and safety of new designs, review of real studies Alexia Iasonos
12.00 - 12.45 TITE-CRM, EWOC: different parameterizations - implications - Graham Wheeler
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12.45 - 14.00 Lunch
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14.00 - 14.45 Semi-parametric methods Matthieu Clertant
14.45 - 15.30 Dose expansion cohorts Alexia Iasonos
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15.30 - 16.00 Coffee break
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16.00 - 16.45 Objective measures of performance, optimal design, theory, getting stuck, overparameterization John O'Quigley
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16.45 Questions and discussion.
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Second day. Thursday, November 16th 2017
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9.00 - 9.30 Coffee, juice, croissants
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9.30 - 10.15 More complex problems; Joint evaluation of efficacy+toxicity, most successful dose John O'Quigley_
10.15 - 11.00 Uncertainty in DLT attribution Alexia Iasonos
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11.00 - 11.15 Coffee break
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11.15 - 12.00 Attribution of toxicities in combinations Graham Wheeler
12.00 - 12.45 Combinations, bridging studies, patient heterogeneity. John O'Quigley
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12.45 - 14.00 Lunch
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14.00 - 14.45 Programs and available software including applications etc. Practical demonstrations. Graham Wheeler
14.45 - 15.30 Protocol Development Alexia Iasonos
15.30 - 16.15 Protocol review- Amendments – EMA/FDA (How to deal with changes in information, updating, correcting errors etc. )